Yesterday we took advantage of some great weather and ate lunch outside while reading the recent neurogenesis-forgetting paper from the Frankland/Josselyn group. It basically flips the field on its head by looking at retrograde effects of neurogenesis on memory, instead of the usual approach of looking at neurogenesis effects on future learning. With the finding being that neurogenesis promotes forgetting of already-formed memories. A few thoughts that emerged from our discussions:
- are good and bad memories forgotten equally? is it always advantageous to forget?
- hilarious that you have to go to the supplementary material to find out the y-axis units for the (19) cell count graphs
- how much does neurogenesis have to increase/decrease to promote/reduce forgetting? Is there a threshold? This stemmed from the observation that normal mice, that do have neurogenesis, show no context fear forgetting between 1-28 days.
- given all the attention this paper is getting, are we going to see an international decline in public health since now everyone is worried that by exercising they might lose all their memories?