Retroviruses can infect actively dividing neural progenitor cells in the hippocampus and spare non-dividing cells such as mature neurons. With this tool we can selectively label newly born neurons. We can infect neuronal precursor cells at various stages in development and look at a neuron’s morphology at certain ages. This…
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In order to investigate the relationship between an animal’s behaviour and neuronal network activity we are looking at immediate early gene activation in neurons after animals learned a task or were exposed to a novel situation for example. This way we can correlate the activity of certain brain regions with…
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The catFISH (cellular Compartment Analysis of Temporal activity by Fluorescence In Situ Hybridization) method allows us to trace back when a specific neuron has been activated. By using labeling for the RNA of the immediate early gene (IEG) zif268 for example, we know that when we detect its RNA in…