Intermittent theta burst transcranial magnetic stimulation induces hippocampal mossy fiber plasticity in male but not female mice PAPER ALERT!!! Tian Rui (Brittany) Zhang is a PhD student in the lab who has been studying the effects of various types of non-invasive stimulation (TMS, ECS) on adult neurogenesis, neuronal activity, and…
Today we have published a new review that was inspired by the controversy over whether adult neurogenesis occurs in humans: JS Snyder (2019) Trends in Neurosciences, DOI:https://doi.org/10.1016/j.tins.2018.12.001 ABSTRACT: Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise questions about its significance for human health and the relevance of animal…
The latest study in the saga that is adult neurogenesis was just published today: Sorrells et al, (2018) Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature, doi:10.1038/nature25975 I wrote a brief piece for Nature News and Views but since they have very strict space limitations I…
This year’s SFN abstracts, for your anticipatory pleasure! INTERACTIONS BETWEEN ADULT-BORN AND DEVELOPMENTALLY-BORN NEURONS DURING LEARNING Alyssa Ash, Jack Clemans-Gibbon, Timothy O’Leary, Erin Chahley, Desiree Seib, Jason Snyder One feature that sets the dentate gyrus (DG) of the hippocampus apart from other regions of the brain is its ability to produce…
Update: This work is now published in Hippocampus, here. The bioRxiv preprint is freely available and nearly identical in content. The Snyder lab’s first paper now exists (pdf here, on bioRxiv). Well, it’s more of a manuscript. Or should I call it a preprint? Does it matter? The thing, as the…
Retroviruses can infect actively dividing neural progenitor cells in the hippocampus and spare non-dividing cells such as mature neurons. With this tool we can selectively label newly born neurons. We can infect neuronal precursor cells at various stages in development and look at a neuron’s morphology at certain ages. This…
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People are definitely way more excited about neurogenesis in adulthood than in early development. Which is fine. But the emphasis on adult neurogenesis has exposed some gaps in our understanding of the developmental process and so we have embarked on a study to compare neurons born are these different stages…