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It’s been a while since we’ve done a lab holiday sporting event. Not sure why exactly, but I guess we just didn’t get around to it for some reason or another. Anyway, we usually like sports that involve heavy objects being projected 25-50 meters or so1. For example, curling or…
Intermittent theta burst transcranial magnetic stimulation induces hippocampal mossy fiber plasticity in male but not female mice PAPER ALERT!!! Tian Rui (Brittany) Zhang is a PhD student in the lab who has been studying the effects of various types of non-invasive stimulation (TMS, ECS) on adult neurogenesis, neuronal activity, and…
Happy to announce a new publication that has been many years1 in the works, “Sex differences in the spatial behavior functions of adult-born neurons in rats“, led by former postdoc Tim O’Leary. In this study, we inhibited adult neurogenesis in female and male transgenic rats to see what happens to…
The lab has 5 presentations to check out at Neuromatch! This is an exciting new venue for online scientific presentation, discussion and collaboration. Interactive talks are short (only 15 min) and supposed to be primarily Q&A, so come with your Qs! Here is a list of our presentations along with…
Hello everyone, this is just a quick note that we (i.e. Matt Cooke and Ricky Ma, with assistance from Brie Dungate) have released a new updated version of Pathfinder. The major changes are 1) the ability to import an increased number of types from various softwares, and 2) a window…
New paper by Desiree et al! Seib, Désirée R., Espinueva, Delane F., Floresco, Stan B., Snyder, Jason S. A role for neurogenesis in probabilistic reward learning. Behavioral Neuroscience. https://doi.org/10.1037/bne0000370 Abstract: Rewards are often unreliable and optimal choice requires behavioral flexibility and learning about the probabilistic nature of uncertain rewards. Probabilistic…
The Pathfinder manuscript is now available here on F1000 Research. Anyone who has run behavioral experiments knows that after running hundreds (or thousands…millions?*) of trials you begin to see patterns that make you wonder if something else is going on that your analyses are not capturing. For people who study learning,…
!!UPDATE!! This paper is now published at the Journal of Neuroscience and you can also find it here. Congratulations to John Darby Cole and Delane Espinueva, two former undergraduate students who led an incredibly detailed study of the morphological development of adult-born neurons. You might read this and think, hasn’t…
Today we have published a new review that was inspired by the controversy over whether adult neurogenesis occurs in humans: JS Snyder (2019) Trends in Neurosciences, DOI:https://doi.org/10.1016/j.tins.2018.12.001 ABSTRACT: Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise questions about its significance for human health and the relevance of animal…
At the recent Society for Neuroscience I presented a dynamic poster, a presentation on a large flatscreen monitor in the giant poster hall. I have seen these around but never had the opportunity to try one before. The project, led by John Darby Cole and Delane Espinueva (who have since…
Snyder lab poster presentations at the 2018 Society for Neuroscience meeting. Stop by and say hi! Sat, Nov. 3 PM. 029.01 / A1 – Adult-born neurons are structurally plastic and remain morphologically distinct from developmentally-born neurons. *J. S. SNYDER, D. ESPINUEVA, T. O’LEARY, S. P. CAHILL, D. SEIB, J. D. COLE…
The latest study in the saga that is adult neurogenesis was just published today: Sorrells et al, (2018) Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature, doi:10.1038/nature25975 I wrote a brief piece for Nature News and Views but since they have very strict space limitations I…
I have long been interested in the culture of science, including publishing practices related to open access and dissemination of scientific knowledge. Given certain career constraints I have identified ~20 potential papers the Snyder Lab should publish in the next couple of years. This has forced my publishing perspective to incorporate some practical…
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The 2017 Neurofutures conference was held at UBC. It was a great opportunity to learn about the latest neuroscience technologies and tools – fluorescent probes, tissue clearing and imaging, expansion microscopy techniques, synthetic protein engineering, and more. The 3rd day was a hands-on workshop on many of the methods that were presented, and…
Many studies on memory and learning utilize the immediate early gene c-Fos as an indicator of recent synaptic activity. By quantifying c-Fos positive neurons, we can compare activity across different populations in the brain, and analyze co-labelled neurons with other useful cell markers such as BrdU and Doublecortin. Our lab…
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Massive turnover in the Snyder Lab this year! In one week alone we had JD, Jerry, Delane and Erin graduate. Not that they all are leaving at this exact instant (“Got my degree, screw you guys I’m outta here!”), but soon. Soon you will also see the fruits of their…
This year’s SFN abstracts, for your anticipatory pleasure! INTERACTIONS BETWEEN ADULT-BORN AND DEVELOPMENTALLY-BORN NEURONS DURING LEARNING Alyssa Ash, Jack Clemans-Gibbon, Timothy O’Leary, Erin Chahley, Desiree Seib, Jason Snyder One feature that sets the dentate gyrus (DG) of the hippocampus apart from other regions of the brain is its ability to produce…
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Plop 30,000 neuroscientists into a downtown core and around 6pm you better be figuring out where you’re going to eat. We found such a place. It was perfect. Then the music turned off and the TV volume went up. Conversation waned. People were fighting! Blood! Joints cracking! But we just want…
Update: This work is now published in Hippocampus, here. The bioRxiv preprint is freely available and nearly identical in content. The Snyder lab’s first paper now exists (pdf here, on bioRxiv). Well, it’s more of a manuscript. Or should I call it a preprint? Does it matter? The thing, as the…
CONFOCAL IMAGING The image files used in this tutorial were taken using a Leica confocal microscope (model SP8). Using fluorescent imaging technique (*) and an extra spatial filter, this confocal can selectively collect light at a specific z-plane, filtering out any out-of-focus illumination. A series of clear 2D images can…